A future-generation non-hormonal contraceptive for women of all ages is becoming d…
A hormone-free women’s contraceptive with no facet consequences is one particular promising use for a new technique formulated by scientists in Sweden to tighten up the mucous membrane – the body’s initially line of protection in shielding its interior lining.
The technique consists of cross-linking the mucus gel with chitosan, a form of polysaccharide derived from chitin, the material that develops in the hard outer shells of crustaceans this kind of as shrimp and crayfish. The content tightens the mucin polymer mesh barrier which lines the mucosal epithelium of our body’s cavities, states Thomas Crouzier, a researcher at KTH Royal Institute of Technologies in Stockholm.
The polymer slowed the diffusion of dextran polymers and cholera protein as a result of the mucous gels, the researchers reported in the recent challenge of Biomacromolecules.
Failure of the mucous barrier can guide to inflammation of the mucosa, which is the problem guiding inflammatory bowel diseases, rhinitis, acid reflux and other syndromes.
And in the cervix, the commonly impervious mucous barrier by natural means gets slack during ovulation, allowing sperm to penetrate and fertilize eggs.
“The polymeric materials can close this possibility, and could protect against fertilization from occurring,” Crouzier claims. “In this way, we get a contraceptive that is not centered on hormones and has no facet consequences.”
By way of his private organization, Crouzier is working toward bringing a merchandise to market place. He says the contraception could be utilized as a little vaginal capsule that quickly dissolves. The blocking impact has been proven to be speedy, in just minutes, he claims.
The 100 % bio-based content creates no unwanted facet consequences simply because it only modifies the superficial mucus layer, irrespective of whether utilised in contraception or other therapies, these kinds of as treatment method of ulcers in mucous membranes and inflammatory bowel conditions.
The scientists have also labored to strengthen other attributes of mucous membranes, this kind of as lubrication and moisturization. Prior perform by the analysis workforce led to development in managing dry mucous membranes.
“The setting up point for us has been to regard mucous membranes as a individual product that you can perform with and modify. In buy to do that, 1 have to recognize the mucous membrane’s functions, which includes acting as a barrier that stops germs and viruses although allowing for oxygen or nutrients to pass as a result of,” he states.
Crouzier is the leader of the Polymers for Everyday living research group at KTH’s School of Engineering Sciences in Chemistry, Biotechnology and Wellbeing, in the Section of Chemistry and the division of Glycoscience. He was supported by KTH Innovation in get to acquire the job closer to the marketplace and patent the creation.
This do the job was funded by a Marie Curie Worldwide Outgoing Fellowship (BIOMUC), and by the Swedish Investigation Council Vetenskapsradet junior challenge grant amount 2014-6203.